4-(6-iodo-2-imidazo[1,2-a]pyridinyl)-N,N-dimethylaniline profile

4-(6-iodo-2-imidazo[1,2-a]pyridinyl)-N,N-dimethylaniline : no description available [CHeBI]

ID Source	ID
PubMed CID	10133297
CHEMBL ID	78012
SCHEMBL ID	913531
CHEBI ID	125592

ID Source

PubMed CID

10133297

CHEMBL ID

78012

SCHEMBL ID

913531

CHEBI ID

125592

Synonyms (20)

Synonym
CHEMBL78012 ,
CHEBI:125592
6-iodo-2-(4''-dimethylamino)phenyl-imidazo[1,2-a]pyridine
4-(6-iodoimidazo[1,2-a]pyridin-2-yl)-n,n-dimethylaniline
4-(6-iodoh-imidazo[1,2-a]pyridin-2-yl)-n,n-dimethylbenzenamine
bdbm50122787
[4-(6-iodo-imidazo[1,2-a]pyridin-2-yl)-phenyl]-dimethyl-amine
2-(4''-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine
6-iodo-2-(4''-n,n''-dimethylamino)phenylimidazo[1,2-a]pyridine)
6-iodo-2-(4''-dimethylamino-)phenyl-imidazo[1,2]pyridine
474012-75-4
benzenamine, 4-(6-iodoimidazo[1,2-a]pyridin-2-yl)-n,n-dimethyl-
BRD-K56622826-001-01-9
SCHEMBL913531
DTXSID40436081
4-(6-iodo-2-imidazo[1,2-a]pyridinyl)-n,n-dimethylaniline
Q27216207
6-iodo-2-(4-dimethylaminophenyl)imidazo[1,2-a]pyridine
2-(49-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine
F75063

Synonym

CHEMBL78012 ,

CHEBI:125592

6-iodo-2-(4''-dimethylamino)phenyl-imidazo[1,2-a]pyridine

4-(6-iodoimidazo[1,2-a]pyridin-2-yl)-n,n-dimethylaniline

4-(6-iodoh-imidazo[1,2-a]pyridin-2-yl)-n,n-dimethylbenzenamine

bdbm50122787

[4-(6-iodo-imidazo[1,2-a]pyridin-2-yl)-phenyl]-dimethyl-amine

2-(4''-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine

6-iodo-2-(4''-n,n''-dimethylamino)phenylimidazo[1,2-a]pyridine)

6-iodo-2-(4''-dimethylamino-)phenyl-imidazo[1,2]pyridine

474012-75-4

benzenamine, 4-(6-iodoimidazo[1,2-a]pyridin-2-yl)-n,n-dimethyl-

BRD-K56622826-001-01-9

SCHEMBL913531

DTXSID40436081

4-(6-iodo-2-imidazo[1,2-a]pyridinyl)-n,n-dimethylaniline

Q27216207

6-iodo-2-(4-dimethylaminophenyl)imidazo[1,2-a]pyridine

2-(49-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine

F75063

Class	Description
imidazoles	A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton.

Class

Description

imidazoles

A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton.

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
Amyloid-beta precursor protein	Homo sapiens (human)	Ki	0.0937	AID1179999; AID1273178; AID265144; AID297920; AID38661; AID445593; AID459782; AID551608; AID726971; AID755101; AID755103; AID760075
Cytochrome P450 2C9	Homo sapiens (human)	Ki	0.0150	AID755103
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.0150	AID755103
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.0150	AID755103
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.0150	AID755103
Cytochrome P450 2D4	Rattus norvegicus (Norway rat)	Ki	0.0080	AID726971

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (27.27)	29.6817
2010's	16 (72.73)	24.3611
2020's	0 (0.00)	2.80

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	22 (100.00%)	84.16%

Substance	Classes	Roles	Relationship Strength
histamine	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter	low
1-(2-trifluoromethylphenyl)imidazole	imidazoles		low
1-methylimidazole	imidazoles		low
4-imidazolemethanol	imidazoles; primary alcohol		low
alosetron	imidazoles; pyridoindole	antiemetic; gastrointestinal drug; serotonergic antagonist	low
azathioprine	aryl sulfide; C-nitro compound; imidazoles; thiopurine	antimetabolite; antineoplastic agent; carcinogenic agent; DNA synthesis inhibitor; hepatotoxic agent; immunosuppressive agent; prodrug	low
bay h 4502	biphenyls; imidazoles		low
brimonidine	imidazoles; quinoxaline derivative; secondary amine	adrenergic agonist; alpha-adrenergic agonist; antihypertensive agent	low
carcinine	beta-alanine derivative; imidazoles; monocarboxylic acid amide; organonitrogen compound; organooxygen compound	antioxidant; crustacean metabolite	low
cgp 20712a	imidazoles		low
cimetidine	aliphatic sulfide; guanidines; imidazoles; nitrile	adjuvant; analgesic; anti-ulcer drug; H2-receptor antagonist; P450 inhibitor	low
clobenpropit	imidazoles; imidothiocarbamic ester; organochlorine compound	H3-receptor antagonist; H4-receptor agonist	low
clotrimazole	conazole antifungal drug; imidazole antifungal drug; imidazoles; monochlorobenzenes	antiinfective agent; environmental contaminant; xenobiotic	low
dacarbazine	imidazoles; monocarboxylic acid amide; triazene derivative	alkylating agent; antineoplastic agent; carcinogenic agent; prodrug	low
dimetridazole	C-nitro compound; imidazoles	antiparasitic agent; antiprotozoal drug	low
econazole	dichlorobenzene; ether; imidazoles; monochlorobenzenes		low
etanidazole	C-nitro compound; imidazoles; monocarboxylic acid amide	alkylating agent; antineoplastic agent; prodrug; radiosensitizing agent	low
flutrimazole	imidazole antifungal drug; imidazoles; monofluorobenzenes	EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor	low
tele-methylhistamine	imidazoles; primary amino compound	human metabolite; mouse metabolite	low
alpha-methylhistamine	aralkylamino compound; imidazoles	animal metabolite; H3-receptor agonist	low
imetit	imidazoles; imidothiocarbamic ester	H3-receptor agonist; H4-receptor agonist	low
isoconazole	dichlorobenzene; ether; imidazoles		low
ketoconazole	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine		low
losartan	biphenylyltetrazole; imidazoles	angiotensin receptor antagonist; anti-arrhythmia drug; antihypertensive agent; endothelin receptor antagonist	low
metronidazole	C-nitro compound; imidazoles; primary alcohol	antiamoebic agent; antibacterial drug; antimicrobial agent; antiparasitic agent; antitrichomonal drug; environmental contaminant; prodrug; radiosensitizing agent; xenobiotic	low
miconazole	dichlorobenzene; ether; imidazoles		low
pd 169316	imidazoles		low
ronidazole	C-nitro compound; carbamate ester; imidazoles	antiparasitic agent; antiprotozoal drug	low
sb 220025	aminopyrimidine; imidazoles; organofluorine compound; piperidines	angiogenesis inhibitor; anti-inflammatory agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	low
sb 239063	imidazoles		low
sb 202190	imidazoles; organofluorine compound; phenols; pyridines	apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	low
sk&f 86002	imidazoles		low
sulconazole	dichlorobenzene; imidazoles; monochlorobenzenes; organic sulfide		low
tinidazole	imidazoles	antiamoebic agent; antibacterial drug; antiparasitic agent; antiprotozoal drug	low
tioconazole	dichlorobenzene; ether; imidazoles; thiophenes		low
tizanidine	benzothiadiazole; imidazoles	alpha-adrenergic agonist; muscle relaxant	low
tolazoline	imidazoles	alpha-adrenergic antagonist; antihypertensive agent; vasodilator agent	low
phentolamine	imidazoles; phenols; substituted aniline; tertiary amino compound	alpha-adrenergic antagonist; vasodilator agent	low
azomycin	C-nitro compound; imidazoles	antitubercular agent	low
5-methylbenzimidazole	imidazoles		low
2-methyl-5-nitroimidazole	C-nitro compound; imidazoles		low
4-methylimidazole	imidazoles	carcinogenic agent; reaction intermediate	low
zolimidine	imidazoles		low
1,2-dimethylimidazole	imidazoles		low
4-nitroimidazole	C-nitro compound; imidazoles		low
metomidate	imidazoles		low
nimorazole	C-nitro compound; imidazoles		low
ipronidazole	C-nitro compound; imidazoles		low
ornidazole	C-nitro compound; imidazoles; organochlorine compound; secondary alcohol	antiamoebic agent; antibacterial drug; antiinfective agent; antiprotozoal drug; antitrichomonal drug; epitope	low
1-(trimethylsilyl)-1h-imidazole	imidazoles; N-silyl compound	chromatographic reagent	low
lofexidine	aromatic ether; carboxamidine; dichlorobenzene; imidazoles	alpha-adrenergic agonist; antihypertensive agent	low
benzonidazole	C-nitro compound; imidazoles; monocarboxylic acid amide	antiprotozoal drug	low
etomidate	imidazoles		low
enilconazole	dichlorobenzene; ether; imidazoles		low
4-methylhistamine	aralkylamino compound; imidazoles	histamine agonist; metabolite	low
climbazole	aromatic ether; hemiaminal ether; imidazoles; ketone; monochlorobenzenes		low
butoconazole nitrate	aryl sulfide; conazole antifungal drug; imidazole antifungal drug; imidazoles; organic nitrate salt		low
butoconazole	aryl sulfide; conazole antifungal drug; dichlorobenzene; imidazole antifungal drug; imidazoles; monochlorobenzenes		low
oxmetidine	benzodioxoles; imidazoles; pyrimidone	anti-ulcer drug; H2-receptor antagonist	low
fenticonazole	aryl sulfide; dichlorobenzene; ether; imidazoles		low
alpidem	imidazoles		low
2-(2-methoxy-4-(methylsulfinyl)phenyl)-1h-imidazo(4,5-c)pyridine	imidazoles		low
sertaconazole	1-benzothiophenes; dichlorobenzene; ether; imidazoles		low
medetomidine	imidazoles		low
zoledronic acid	1,1-bis(phosphonic acid); imidazoles	bone density conservation agent	low
n-acetylhistamine	acetamides; imidazoles	human metabolite	low
5-imidazolepropionic acid	imidazoles; monocarboxylic acid		low
secnidazole	C-nitro compound; imidazoles; secondary alcohol	epitope	low
nitrefazole	imidazoles		low
eberconazole	dibenzannulene; imidazoles; organochlorine compound		low
prochloraz	amide fungicide; aromatic ether; conazole fungicide; imidazole fungicide; imidazoles; trichlorobenzene; ureas	antifungal agrochemical; EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor; environmental contaminant; xenobiotic	low
methylimidazoleacetic acid	imidazoles; monocarboxylic acid	GABA agonist; metabolite	low
5-(3-methyl-1-triazeno)imidazole-4-carboxamide	imidazoles; monocarboxylic acid amide; triazene derivative	alkylating agent; antineoplastic agent	low
1-(3-aminopropyl)imidazole	imidazoles		low
1-ethyl-2-benzimidazolinone	imidazoles		low
2-methylhistamine	aralkylamino compound; imidazoles	histamine agonist; metabolite	low
imidazoleacetic acid	imidazoles; monocarboxylic acid	metabolite; mouse metabolite	low
mizoribine	imidazoles	anticoronaviral agent	low
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1h-imidazole	ether; imidazoles; monomethoxybenzene	TRP channel blocker	low
exp3174	biphenylyltetrazole; imidazoles; organochlorine compound	metabolite	low
1-(2-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole	C-nitro compound; imidazoles		low
histidinal	amino aldehyde; imidazoles		low
alpha-methylhistamine	aralkylamino compound; imidazoles	H3-receptor agonist	low
tipifarnib	imidazoles; monochlorobenzenes; primary amino compound; quinolone	antineoplastic agent; apoptosis inducer; EC 2.5.1.58 (protein farnesyltransferase) inhibitor	low
histidinol	amino alcohol; imidazoles	EC 2.3.1.97 (glycylpeptide N-tetradecanoyltransferase) inhibitor; Escherichia coli metabolite; human metabolite; Saccharomyces cerevisiae metabolite	low
sb 203580	imidazoles; monofluorobenzenes; pyridines; sulfoxide	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector; Hsp90 inhibitor; neuroprotective agent	low
fk 1052	imidazoles; organic heterotricyclic compound	antiemetic; serotonergic antagonist	low
cimicoxib	aromatic ether; imidazoles; organochlorine compound; organofluorine compound; sulfonamide	cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug	low
dabuzalgron	aromatic ether; imidazoles; monochlorobenzenes; sulfonamide	alpha-adrenergic agonist	low
l 778,123	imidazoles; monochlorobenzenes; nitrile; piperazinone; tertiary amino compound	antineoplastic agent; EC 2.5.1.58 (protein farnesyltransferase) inhibitor; EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor	low
1-methylpropyl-2-imidazolyl disulfide	imidazoles		low
2-pentan-3-yl-1H-imidazole	imidazoles		low
2-(1-adamantyl)imidazole	imidazoles		low
6-(4-chlorophenyl)-2,3-dihydroimidazo[2,1-b]thiazole	imidazoles		low
bromodeoxytopsentin	aromatic ketone; bromoindole; imidazoles; indole alkaloid	antibacterial agent; EC 2.7.1.40 (pyruvate kinase) inhibitor; marine metabolite	low
pifithrin-beta	imidazoles		low
bms 214662	benzenes; benzodiazepine; imidazoles; nitrile; sulfonamide; thiophenes	antineoplastic agent; apoptosis inducer; EC 2.5.1.58 (protein farnesyltransferase) inhibitor	low
histidyl-proline diketopiperazine	dipeptide; homodetic cyclic peptide; imidazoles; pyrrolopyrazine	anti-inflammatory agent; dopamine uptake inhibitor; human blood serum metabolite	low
s 1033	(trifluoromethyl)benzenes; imidazoles; pyridines; pyrimidines; secondary amino compound; secondary carboxamide	anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor	low
N-[1-methyl-5-(4-methylphenyl)-2-imidazolyl]-4-oxo-4-(1-piperidinyl)butanamide	imidazoles		low
2-[[5-(4-fluorophenyl)-1-methyl-2-imidazolyl]thio]-1-(1-piperidinyl)ethanone	imidazoles		low
2-[[5-(4-chlorophenyl)-1-(2-methoxyethyl)-2-imidazolyl]thio]-N-(thiophen-2-ylmethyl)acetamide	imidazoles		low
2-(4-chlorophenyl)-3-(2-furanylmethyl)imidazo[4,5-b]quinoxaline	imidazoles		low
2-(4-methoxyphenyl)-3-propylimidazo[4,5-b]quinoxaline	imidazoles		low
etomidate	ethyl ester; imidazoles	intravenous anaesthetic; sedative	low
4-(3-amino-2-imidazo[1,2-a]pyridinyl)-2-methoxyphenol	imidazoles		low
aeg 3482	imidazoles		low
2-(3,4-dichlorophenyl)imidazo[1,2-a]pyrimidine	imidazoles		low
1-hydroxy-2-phenyl-1,5,6,7-tetrahydro-4H-benzimidazol-4-one	imidazoles		low
3-(4-methoxyphenyl)imidazo[1,5-a]pyridine	imidazoles		low
N-(2-phenyl-3-imidazo[1,2-a]pyridinyl)carbamic acid methyl ester	imidazoles		low
N-[3-(6-imidazo[2,1-b]thiazolyl)phenyl]butanamide	imidazoles		low
N-(6-phenyl-5-imidazo[2,1-b]thiazolyl)benzamide	imidazoles		low
2-phenyl-3-imidazo[1,2-a]pyridinecarboxaldehyde	imidazoles		low
N-(2-phenyl-6-imidazo[1,2-a]pyridinyl)acetamide	imidazoles		low
N,N-dimethylcarbamic acid [4-[6-(trifluoromethyl)-2-imidazo[1,2-a]pyridinyl]phenyl] ester	imidazoles		low
2-(2-furanyl)-3-(4-methylphenyl)imidazo[4,5-b]quinoxaline	imidazoles		low
2-[(1,5-diphenyl-2-imidazolyl)thio]-N-(2-furanylmethyl)acetamide	imidazoles		low
4-chloro-2-[[(1-methyl-5-phenyl-2-imidazolyl)amino]methyl]phenol	imidazoles		low
5-(4-bromophenyl)-1-methyl-N-(3-pyridinylmethyl)-2-imidazolamine	imidazoles		low
N'-methyl-N-[1-methyl-5-(4-methylphenyl)-2-imidazolyl]-N'-(phenylmethyl)butanediamide	imidazoles		low
5-(4-fluorophenyl)sulfonyl-1-(2-methylpropyl)-4-nitro-2-propan-2-ylimidazole	imidazoles		low
2-(3,5-dinitrophenyl)-3-(2-phenylethyl)imidazo[4,5-b]quinoxaline	imidazoles		low
2-(4-methylsulfonylphenyl)-6-imidazo[1,2-a]pyridinecarboxylic acid methyl ester	imidazoles		low
1-[[[1-(6-methyl-2-pyridinyl)-4-imidazolyl]-oxomethyl]amino]-3-phenylthiourea	imidazoles		low
metiamide	imidazoles		low
4,5-dichloro-2-methyl-1-(2-phenoxyethyl)imidazole	imidazoles		low
2-Chloro-6-(1H-imidazol-1-yl)benzonitrile	imidazoles		low
[1-Benzyl-2-(methylsulfanyl)-1H-imidazol-5-yl]methanol	imidazoles		low
2-(1-benzyl-1H-imidazol-5-yl)phenol	imidazoles		low
1-[2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-nitrophenyl]-1H-imidazole	imidazoles		low
2-[4-(trifluoromethoxy)phenyl]imidazo[1,2-a]pyrimidine	imidazoles		low
6-methyl-2-[4-(1-piperidinylsulfonyl)phenyl]imidazo[1,2-a]pyridine	imidazoles		low
1-[(4-tert-butylphenyl)methyl]-4-(4-nitrophenyl)imidazole	imidazoles		low
burimamide	imidazoles		low
carnidazole	C-nitro compound; imidazoles		low
2-methoxy-4-[5-methyl-3-(2-oxolanylmethylamino)-2-imidazo[1,2-a]pyridinyl]phenol	imidazoles		low
4-[3-(1,3-benzodioxol-5-ylmethylamino)-7-methyl-2-imidazo[1,2-a]pyridinyl]phenol	imidazoles		low
2-[[5-(4-fluorophenyl)-1-methyl-2-imidazolyl]thio]-1-(2-methyl-2,3-dihydroindol-1-yl)ethanone	imidazoles		low
N-[3-(diethylamino)propyl]-6-(4-fluorophenyl)-3-methyl-2-imidazo[2,1-b]thiazolecarboxamide	imidazoles		low
N-(1,3-benzodioxol-5-yl)-3-methyl-6-phenyl-2-imidazo[2,1-b]thiazolecarboxamide	imidazoles		low
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-2-[[1-(3-methylphenyl)-2-imidazolyl]thio]acetamide	imidazoles		low
4-[[2-(4-methoxyphenyl)-6-imidazo[2,1-b][1,3]benzothiazolyl]-oxomethyl]-1-piperazinecarboxylic acid ethyl ester	imidazoles		low
4-[3-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-imidazo[1,2-a]pyrimidinyl]phenol	imidazoles		low
5-(1,3-benzodioxol-5-yl)-3-[3-(methylthio)phenyl]-1H-imidazol-2-one	imidazoles		low
2-(2-ethoxyphenyl)-8-oxo-9-phenyl-7H-purine-6-carboxamide	imidazoles		low
1-phenyl-2-[[4-(trifluoromethyl)phenyl]methylthio]imidazole	imidazoles		low
1-[6-(4-chlorophenyl)-5-imidazo[2,1-b]thiazolyl]-N-[(3,4-dichlorophenyl)methoxy]methanimine	imidazoles		low
1-[4-(2-chlorophenoxy)butyl]imidazole	aromatic ether; imidazoles; monochlorobenzenes		low
4-[(3-methyl-5-nitro-4-imidazolyl)amino]phenol	C-nitro compound; imidazoles		low
4-(4-ethoxyphenyl)-1-(4-methoxyphenyl)-2-(methylthio)imidazole	imidazoles		low
4-[(7-methyl-2-phenyl-3-imidazo[1,2-a]pyridinyl)methyl]morpholine	imidazoles		low
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide	benzamides; benzodioxoles; imidazoles; pyridines	EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	low
1-(3,4-dihydro-2H-quinolin-1-yl)-2-[[1-(4-ethoxyphenyl)-2-imidazolyl]thio]ethanone	imidazoles		low
2-[[1-(3-methoxyphenyl)-2-imidazolyl]thio]-N-(5-methyl-3-isoxazolyl)acetamide	imidazoles		low
N-(4-tert-butylphenyl)-2-[4-(1-imidazolyl)phenoxy]acetamide	imidazoles		low
2-[[4-(3,4-dimethylphenyl)-1-phenyl-2-imidazolyl]thio]-N-(1,1-dioxo-3-thiolanyl)acetamide	imidazoles		low
6-(4-methoxyphenyl)-N,3-dimethyl-2-imidazo[2,1-b]thiazolecarboxamide	imidazoles		low
eprosartan	dicarboxylic acid; imidazoles; thiophenes	angiotensin receptor antagonist; antihypertensive agent; environmental contaminant; xenobiotic	low
neticonazole	aromatic ether; benzenes; conazole antifungal drug; enamine; imidazole antifungal drug; imidazoles; methyl sulfide	antifungal drug; EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor	low
2-(2-chlorophenyl)-9-(3-methylphenyl)-8-oxo-7H-purine-6-carboxamide	imidazoles		low
N-[(3-methyl-6-imidazo[2,1-b]thiazolyl)methyl]-1-propanesulfonamide	imidazoles		low
oxiconazole	conazole antifungal drug; dichlorobenzene; imidazole antifungal drug; imidazoles; oxime O-ether	antiinfective agent	low
3-[(1S)-1-phenylethyl]-4-imidazolecarboxylic acid ethyl ester	imidazoles		low
d 4476	imidazoles		low
azanidazole	C-nitro compound; imidazoles		low
4-[4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1H-imidazol-5-yl]pyridine	imidazoles		low
N-[5-(2-imidazo[1,2-a]pyrimidinyl)-2-methoxyphenyl]-2-methylpropanamide	imidazoles		low
4-[3-(3-methylanilino)-2-imidazo[1,2-a]pyrimidinyl]phenol	imidazoles		low
2-[4-(dimethylamino)phenyl]-N-(4-methylphenyl)-3-imidazo[1,2-a]pyrimidinamine	imidazoles		low
N-(1,3-benzodioxol-5-yl)-2-(4-methylphenyl)-3-imidazo[1,2-a]pyrazinamine	imidazoles		low
sb-505124	benzodioxole; imidazoles; methylpyridines	TGFbeta receptor antagonist	low
cyazofamid	imidazole fungicide; imidazoles; nitrile; organochlorine compound; sulfamides; sulfonamide fungicide	antifungal agrochemical; mitochondrial cytochrome-bc1 complex inhibitor	low
npi 2358	2,5-diketopiperazines; benzenes; imidazoles; olefinic compound	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; microtubule-destabilising agent	low
l-779,450	imidazoles		low
chir 99021	aminopyridine; aminopyrimidine; cyanopyridine; diamine; dichlorobenzene; imidazoles; secondary amino compound	EC 2.7.11.26 (tau-protein kinase) inhibitor	low
eluxadoline	amino acid amide; benzamides; imidazoles; L-phenylalanine derivative; methoxybenzoic acid	delta-opioid receptor antagonist; gastrointestinal drug; kappa-opioid receptor agonist; mu-opioid receptor agonist	low
cenicriviroc	aromatic ether; benzazocine; diether; imidazoles; secondary carboxamide; sulfoxide	anti-HIV agent; anti-inflammatory agent; antirheumatic drug; chemokine receptor 2 antagonist; chemokine receptor 5 antagonist	low
4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3h-imidazol-4-yl)pyrimidin-2-ylamine	aminopyrimidine; imidazoles; monofluorobenzenes	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor	low
imidazoleacetic acid ribotide	imidazoles; monocarboxylic acid; N-glycosyl compound; ribose monophosphate		low
cefpodoxime	imidazoles		low
sgi 1776	imidazoles		low
bms-790052	biphenyls; carbamate ester; carboxamide; imidazoles; valine derivative	antiviral drug; nonstructural protein 5A inhibitor	low
9-(3,5-difluorophenyl)-6-(ethylamino)-2-purinecarbonitrile	imidazoles		low
chir 98014	aminopyrimidine; C-nitro compound; diaminopyridine; dichlorobenzene; imidazoles; secondary amino compound	antineoplastic agent; apoptosis inducer; EC 2.7.11.26 (tau-protein kinase) inhibitor; hypoglycemic agent; tau aggregation inhibitor; Wnt signalling activator	low
ledipasvir	azaspiro compound; benzimidazole; bridged compound; carbamate ester; carboxamide; fluorenes; imidazoles; L-valine derivative; N-acylpyrrolidine; organofluorine compound	antiviral drug; hepatitis C protease inhibitor	low
gs-5816	carbamate ester; ether; imidazoles; L-valine derivative; N-acylpyrrolidine; organic heteropentacyclic compound; ring assembly	antiviral drug; hepatitis C virus nonstructural protein 5A inhibitor	low
mk-8742	carbamate ester; imidazoles; L-valine derivative; N-acylpyrrolidine; organic heterotetracyclic compound; ring assembly	antiviral drug; hepatitis C virus nonstructural protein 5A inhibitor; hepatoprotective agent	low
sb-590885	aromatic ether; imidazoles; ketoxime; pyridines; tertiary amino compound		low

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	2000's	2010's
cgp 52411	1	phthalimides	geroprotector; tyrosine kinase inhibitor	2010	2010	14.0	low	1	0
congo red	1	bis(azo) compound		2010	2010	14.0	low	1	0
thioflavin t	2	organic chloride salt	fluorochrome; geroprotector; histological dye	2010	2010	14.0	low	2	0
naproxen	1	methoxynaphthalene; monocarboxylic acid	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; environmental contaminant; gout suppressant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic	2010	2010	14.0	low	1	0
chrysamine g	1			2010	2010	14.0	low	1	0
dibenzylidene acetone	1			2011	2011	13.0	low	0	1
(1E,4E)-1,5-bis(4-methoxyphenyl)penta-1,4-dien-3-one	1	methoxybenzenes		2011	2011	13.0	medium	0	1
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole	5			2006	2011	14.4	medium	3	2
2-(4-(dimethylamino)styryl)benzothiazole	1			2010	2010	14.0	medium	1	0
2-(4'-methylaminophenyl)benzothiazole	1			2010	2010	14.0	medium	1	0
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole	9			2006	2015	13.4	high	5	4
bay94 9172	4	(18)F radiopharmaceutical; aromatic ether; polyether; secondary amino compound; stilbenoid; substituted aniline	radioactive imaging agent	2009	2013	13.0	high	1	3
vizamyl	1	(18)F radiopharmaceutical; aromatic amine; benzothiazoles; secondary amino compound	radioactive imaging agent	2011	2011	13.0	high	0	1
florbetapir f 18	6	(18)F radiopharmaceutical; aromatic ether; organofluorine compound; pyridines; substituted aniline	radioactive imaging agent	2010	2015	11.8	medium	1	5

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	2000's	2010's
Acute Confusional Senile Dementia	16	2003	2015	14.4	high	9	7
Alzheimer Disease	16	2003	2015	14.4	high	9	7
Amyloid Angiopathy, Cerebral	1	2011	2011	13.0	low	0	1
Amyloid Deposits	11	2006	2015	12.8	high	3	8
Cerebral Amyloid Angiopathy	1	2011	2011	13.0	low	0	1
Disease Models, Animal	2	2011	2013	12.0	low	0	2

Assay ID	Title	Year	Journal	Article
AID445593	Binding affinity to Beta amyloid aggregates in Alzheimer's disease patient brain by competitive binding assay	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 ISSN: 1520-4804	18F stilbenes and styrylpyridines for PET imaging of A beta plaques in Alzheimer's disease: a miniperspective.
AID755101	Displacement of [125I]IMPY from amyloid beta (1 to 42) (unknown origin) after 3 hrs by gamma counting analysis	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13 ISSN: 1464-3391	Synthesis and biological evaluation of 18F-labled 2-phenylindole derivatives as PET imaging probes for β-amyloid plaques.
AID297920	Binding affinity to human beta amyloid plaque in alzheimer's disease patient brain	2007	Journal of medicinal chemistry, Sep-20, Volume: 50, Issue:19 ISSN: 0022-2623	Synthesis and structure-affinity relationships of new 4-(6-iodo-H-imidazo[1,2-a]pyridin-2-yl)-N-dimethylbenzeneamine derivatives as ligands for human beta-amyloid plaques.
AID11540	Biodistribution of radioactivity in normal mice (ICR) liver after 6 hours of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID11535	Biodistribution of radioactivity in normal mice (ICR) liver after 1 hour of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID11373	Biodistribution of radioactivity in normal mice (ICR) heart after 6 hours of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID11566	Biodistribution of radioactivity in normal mice blood after 2 hours of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID551608	Displacement of [125I]DMIC from Amyloid beta (1 to 42) after 3 hrs by gamma counting	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 ISSN: 1464-3405	Diphenylpropynone derivatives as probes for imaging β-amyloid plaques in Alzheimer's brains.
AID11551	Biodistribution of radioactivity in normal mice (ICR) muscle after 30 minutes of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID11542	Biodistribution of radioactivity in normal mice (ICR) lung after 2 hours of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID594160	Displacement of [3H]BTA-1 from amyloid beta 1 to 40 by competitive binding assay	2011	Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 ISSN: 1464-3405	2-Arylimidazo[2,1-b]benzothiazoles: a new family of amyloid binding agents with potential for PET and SPECT imaging of Alzheimer's brain.
AID11376	Biodistribution of radioactivity in normal mice (ICR) kidney after 2 minutes of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID603595	Displacement of [125I]-IMPY from amyloid beta (1 to 42) after 2 hrs by gamma counting	2011	Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13 ISSN: 1464-3391	Synthesis and evaluation of benzofuran-2-yl(phenyl)methanone derivatives as ligands for β-amyloid plaques.
AID11549	Biodistribution of radioactivity in normal mice (ICR) muscle after 2 minutes of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID11559	Biodistribution of radioactivity in normal mice (ICR) spleen after 1 hour of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID265144	Displacement of [125I]IMPY from beta amyloid in human AD cortical tissue	2006	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11 ISSN: 0960-894X	Synthesis and evaluation of two 18F-labeled imidazo[1,2-a]pyridine analogues as potential agents for imaging beta-amyloid in Alzheimer's disease.
AID459782	Displacement of [125I-N-Methyl-4-(4-bromoanilino)phthalimide from beta-amyloid plaques isolated from Alzheimer's disease patient brain	2010	Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3 ISSN: 1464-3391	Novel anilinophthalimide derivatives as potential probes for beta-amyloid plaque in the brain.
AID11546	Biodistribution of radioactivity in normal mice (ICR) lung after 6 hours of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID11534	Biodistribution of radioactivity in normal mice (ICR) kidney after 6 hours of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID11375	Biodistribution of radioactivity in normal mice (ICR) kidney after 2 hours of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID11552	Biodistribution of radioactivity in normal mice (ICR) muscle after 6 hours of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID568693	Displacement of [125I]IMPY from amyloid beta 1 to 42 after 2 hrs	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 ISSN: 1464-3405	Synthesis and biological evaluation of indole-chalcone derivatives as β-amyloid imaging probe.
AID11564	Biodistribution of radioactivity in normal mice (ICR) spleen after 6 hours of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID11365	Biodistribution of radioactivity in normal mice (ICR) brain after 24 hours of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID11568	Biodistribution of radioactivity in normal mice blood after 24 hours of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID593867	Displacement of [125I]IMPY from amyloid beta (1 to 42) aggregate after 2 hrs by gamma counting	2011	Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7 ISSN: 1520-4804	Synthesis and structure-affinity relationships of novel dibenzylideneacetone derivatives as probes for β-amyloid plaques.
AID11555	Biodistribution of radioactivity in normal mice (ICR) skin after 2 minutes of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID11371	Biodistribution of radioactivity in normal mice (ICR) heart after 24 hours of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID264494	Displacement of [125I](E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)styrylbenzene from beta amyloid peptide in brain tissue at 50 uL	2006	Journal of medicinal chemistry, May-04, Volume: 49, Issue:9 ISSN: 0022-2623	Synthesis of biphenyltrienes as probes for beta-amyloid plaques.
AID11368	Biodistribution of radioactivity in normal mice (ICR) heart after 1 hour of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID11561	Biodistribution of radioactivity in normal mice (ICR) spleen after 2 minutes of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID760075	Displacement of [125I]IMPY from amyloid beta (1 to 42) (unknown origin) after 3 hrs by gamma counting	2013	ACS medicinal chemistry letters, Jul-11, Volume: 4, Issue:7 ISSN: 1948-5875	Structure-Activity Relationships and in Vivo Evaluation of Quinoxaline Derivatives for PET Imaging of β-Amyloid Plaques.
AID11569	Biodistribution of radioactivity in normal mice blood after 30 minutes of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID11544	Biodistribution of radioactivity in normal mice (ICR) lung after 24 hours of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID11550	Biodistribution of radioactivity in normal mice (ICR) muscle after 24 hours of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID11543	Biodistribution of radioactivity in normal mice (ICR) lung after 2 minutes of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID755103	Displacement of [125I]IMPY from amyloid beta (1 to 40) (unknown origin) after 3 hrs by gamma counting analysis	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13 ISSN: 1464-3391	Synthesis and biological evaluation of 18F-labled 2-phenylindole derivatives as PET imaging probes for β-amyloid plaques.
AID11557	Biodistribution of radioactivity in normal mice (ICR) skin after 30 minutes of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID11370	Biodistribution of radioactivity in normal mice (ICR) heart after 2 minutes of intravenous injection of [125I]-16(IMPY)	2003	Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2 ISSN: 0022-2623	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
AID1179999	Displacement of [125I]1-Iodo-4-((4-methoxyphenoxy)methyl)benzene from amyloid beta42 (unknown origin) after 3 hrs by gamma counting	2014	Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 ISSN: 1520-4804	Radioiodinated benzyloxybenzene derivatives: a class of flexible ligands target to β-amyloid plaques in Alzheimer's brains.

4-(6-iodo-2-imidazo[1,2-a]pyridinyl)-N,N-dimethylaniline

Description

Cross-References

Synonyms (20)

Drug Classes (1)

Protein Targets (6)

Inhibition Measurements

Bioassays (80)

Research

Studies (22)

Study Types

Related Drugs (200)

Drugs in this Class (187)

Drugs Involved in Assays Together (13)

Related Conditions (6)